同济大学学报（医学版）2011，Vol.32Issue(5)：77-79,82,4.DOI:10.3969/j.issn1008-0392.2011.05.017
5-氨基酮戊酸光动力疗法联合二氧化碳激光治疗尖锐湿疣的疗效观察
5-aminolevulinic acid-mediated photodynamic therapy combined with CO2 laser therapy in treatment of condyloma acuminatum
顾俊瑛 1史玉玲 1李秀丽 1李晓建 1刘至昱 1高飞1
作者信息
- 1. 同济大学附属第十人民医院皮肤科,上海200072
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) combined with CO2 laser therapy in treatment of condyloma acuminatum. Methods One hundred and eleven patients with condyloma acuminatum admitted from April to December 2010 were enrolled in the study. Seventeen cases whose condylomas are at urethral orifice, vinculum or cervix uteri were treated with ALA-PDT alone. Other 94 cases were randomly assigned into two groups with 47 in each, who were treated by ALA-PDT combined with CO2 laser therapy or CO2 laser alone, respectively. Results The clearance rate was 93. 4% (16/17) and the relapse rate was 11.8% (2/17) in patients treated with ALA-PDT alone. The relapse rates of ALA-PDT combined with CO2 laser and CO2 laser alone were 14. 9% (7/47 ) and 55. 3% (26/47 ) , respectively (x2 = 16. 857, P < 0. 001). Conclusion ALA-PDT is effective in treatment of condyloma acuminatum in special locations with low relapse rate. ALA-PDT combined with CO2 laser therapy has a better effect and lower relapse rate in treating condyloma acuminatum than CO2 laser therapy alone.关键词
尖锐湿疣/5-氨基酮戊酸光动力疗法:CO2激光Key words
condyloma acuminatum/ 5-amindevulinic acid-mediated photodynamic therapy/ CO2 laser分类
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顾俊瑛,史玉玲,李秀丽,李晓建,刘至昱,高飞..5-氨基酮戊酸光动力疗法联合二氧化碳激光治疗尖锐湿疣的疗效观察[J].同济大学学报（医学版）,2011,32(5):77-79,82,4.
