摘要
Abstract
Objective To investigate the phosphorus levels in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) and related influencing factors. Methods Fifty-eight stable CAPD patients were enrolled in the study. Dietary survey was conducted, estimated residual kidney function(KRF) and dialysis adequacy were evaluated. Serum phosphate, calcium, intact parathyroid hormone(IPTH), albumin(ALB) , pre-albumin(PA), lipids, endothelin(ET) and C-reactive protein (CRP) were measured. Results The levels of serum phosphate and IPTH were decreased after dialysis in CAPD patients (P < 0. 01) , 26 of 58 (45% ) patients had hyperphosphatemia. Serum phosphate levels were positively correlated with dietary phosphate, cholesterol, protein and energy intake(r = 0.575,r = 0.449, r = 0. 353 and r = 0.367, respectively;P < 0.01). Serum phosphate levels were not correlated with dialysis adequacy and RRF, but correlated with serum urea nitrogen and creatinine(r = 0.578, r = 0. 560, respectively; P < 0. 01). Serum phosphate levels were positively correlated with serum albumin and pre-albumin ( r = 0. 269, P < 0. 05; r = 0. 404, P < 0. 01 ), and negatively correlated with TC and LDL levels(r= -0.407,r= -0.311 ;P <0.01). Serum phosphate levels were also positively correlated with ET( r = 0.359; P <0.01). Conclusion CAPD contributes to improve calcium-phosphate metabolism disorder. Serum phosphate levels are associated with dietary intake and uremic toxin accumulation. Hyperphosphatemia may stimulate ET release.关键词
腹膜透析/高磷血症/内皮素Key words
peritoneal dialysis/ hyperphosphatemia/ endothelin分类
医药卫生
