解放军医学杂志2011，Vol.36Issue(11)：1203-1206,4.
丙泊酚麻醉下静脉注射多巴胺对脑电监测指标及镇静评分的影响
Effect of intravenous injection of dopamine on the bispectral index, entropy index, and sedation score during continuous propofol infusion
薛纪秀 1徐国勋 1刘清海 1王克杰 1王天龙 1李冰 1杨利利1
作者信息
- 1. 100053 北京 首都医科大学宣武医院麻醉科
- 折叠
摘要
Abstract
Objective To examine the effect of an intravenous injection of dopamine on the bispectral index (BIS), entropy index, and sedation score [Observer's Assessment of Alertness/Sedation (OAAS)] during continuous propofol infusion. Methods The present study selected nine patients undergoing an operation under ASA Ⅰ-Ⅱ general anesthesia. Propofol is administered for anesthesia, and plasma/effective concentration (Cp/Ce) remained unchanged when OAA/S=2. An intravenous injection of dopamine is then administrated at a single injection dosage of 3 mg to 5 mg. BIS, response entropy (RE), state entropy (SE) , OAA/S score, and mean arterial pressure (MAP) are recorded 1 min before injection and 1 min to 5 min after injection. Results Cp/Ce is 1. 71±0. 42 when OAA/S=2. After the intravenous injection of dopamine, BIS increases remarkably in five cases (BIS>70 in four cases). The increment primarily occurs at 3 and 4 min. The entropy index in nine cases begins to increase at 2min, with this index apparently higher than that before the injection in six cases. The difference between RE and SE increases, and the increment of BIS and the entropy index occurs later than MAP. The OAA/S score ≥4 in five cases. Conclusion Intravenous injection of dopamine results in higher BIS, entropy index, and sedation score during a continuous infusion of propofol when OAA/S- 2, thereby having an arousal effect. The entropy index is sensitive in terms of reflecting the arousal effect of dopamine.关键词
二异丙酚/麻醉/多巴胺/双频谱指数/熵/镇静评分Key words
propofol/ anesthesia/ dopamine/ bispectral index/ entropy/ sedation score分类
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薛纪秀,徐国勋,刘清海,王克杰,王天龙,李冰,杨利利..丙泊酚麻醉下静脉注射多巴胺对脑电监测指标及镇静评分的影响[J].解放军医学杂志,2011,36(11):1203-1206,4.
