国际病理科学与临床杂志2011，Vol.31Issue(5)：381-384,4.DOI:10.3969/j.issn.1673-2588.2011.10.003
经皮氧分压联合踝臂指数在2型糖尿病合并下肢动脉病变中的临床应用
Clinical applications of transcutaneous oxygen pressure combined with ankle-brachial index in Type 2 diabetics with peripheral arterial disease
李梦娟 1李素梅 1汝燕 1王芳 1王菊梅 1荆春艳 1王东 1董林 1任安1
作者信息
- 1. 安徽医科大学附属省立医院内分泌科,合肥230001
- 折叠
摘要
Abstract
Objective To compare the clinical application in diagnosis and therapy for Type 2 diabetes patients with perpheral arterial diease ( PAD) between transcutaneous oxygen pressure ( TcPO2 ) determination and ankle-brachial index (ABI). Methods A total of 368 Type 2 diabetics (188 males and 180 females) were recruited into the study. TcPO2 of the acrotarsium was detected by multiple-channel transcutaneous tissue oxygen tension survey meter. According to die TcPO2 level, diese patients were divided into a non-injury group, a mild injury group, and a severe injury group. Moreover,the ankle artery pressure and brachial artery pressure were determined by Doppler color ultrasonography and die ABI was calculated. According to the level of ABI, the patients were divided into a non pathological change group (ABI 2:0.9) and a PAD group (ABI <0. 9). Results Indexes including the age, duration ofdiabetes, incidence of diabetes associated with coronary heart disease, fasting blood glucose ( FBG) , 2-hour postprandial blood glucose, glycated hemoglobin Al c and urinary creatinine in the PAD group were markedly higher than those in the non pathological change group, whereas the TcPO2 in the PAD group was lower than that in the non pathological change group. Correlation analysis showed that TcPO2 was negatively related with the age, duration of diabetes, FBG, triglyceride, glycated hemoglobin Al c and body mass index while TcPO2 was positively related with the high density lipoprotein and ABI. The concordance rate of detection results for TcPO2 and ABI was 93. 9% . The sensibility and specificity was 90.2% and 95.2% respectively. Conclusion With the progress of diabetes and the increase in ratio of urinary albumin to creatinine, the degree of peripheral arterial disease are increased. The ABI and TcPO2 are negatively related with the degree of peripheral arterial disease. TcPO2 combined with ABI have a profound value in the early diagnosis of Type 2 diabetics with peripheral arterial disease.关键词
糖尿病/下肢动脉病变/经皮氧分压/踝臂指数Key words
diabetes mellitus/ transcutaneous oxygen pressure/ peripheral arterial disease/ ankle-brachial index引用本文复制引用
李梦娟,李素梅,汝燕,王芳,王菊梅,荆春艳,王东,董林,任安..经皮氧分压联合踝臂指数在2型糖尿病合并下肢动脉病变中的临床应用[J].国际病理科学与临床杂志,2011,31(5):381-384,4.
