动物学研究2011，Vol.32Issue(5)：499-503,5.DOI:10.3724/SP.J.1141.2011.05499
中国汉族人群中RELN基因rs7341475位点与精神分裂症的相关性分析
Association of RELN SNP rs7341475 with schizophrenia in the Chinese population
刘兴彦 1李明 2杨顺英 3宿兵 1尹利德2
作者信息
- 1. 玉溪市第二人民医院,玉溪653101
- 2. 中国科学院昆明动物研究所遗传资源与进化国家重点实验室,昆明650223
- 3. 中国科学院研究生院,北京100049
- 折叠
摘要
Abstract
Schizophrenia is a common and complex psychiatric disorder. Significant evidence has suggested that genetic factors play pivotal roles in the etiology of schizophrenia. More than 100 schizophrenia candidate genes have been reported; however, many of them do not have satisfactory replications among different populations. Among these genes, RELN is thought to be associated with schizophrenia in many populations, suggesting it is a real risk gene for this disorder. Identified in the GWAS study, single nucleotide polymorphism (SNP) rs7341475, located in intron 4 of RELN, has been successfully replicated in subsequent investigations, implying its potential contribution to schizophrenia susceptibility. To investigate the association of rs7341475 with schizophrenia in Chinese populations, a case-control association analysis was conducted with samples from Yuxi (400 cases and 400 controls) in southwestern China. The results do not indicate any association of rs7341475 with schizophrenia, which suggests it is not a risk SNP for schizophrenia in Han Chinese.关键词
精神分裂症/RELN/单核苷酸多态性位点/中国人群Key words
Schizophrenia/ RELN/ Single nucleotide polymorphism/ Chinese population分类
生物科学引用本文复制引用
刘兴彦,李明,杨顺英,宿兵,尹利德..中国汉族人群中RELN基因rs7341475位点与精神分裂症的相关性分析[J].动物学研究,2011,32(5):499-503,5.
