国际病理科学与临床杂志2011，Vol.31Issue(5)：424-429,6.DOI:10.3969/j.issn.1673-2588.2011.10.012
蛋白14-3-3蛋白亚型与癌症
Protein 14-3-3 isoforms and cancers
摘要
Abstract
The 14-3-3 protein family in eukaryotic cells is widely expressed and highly conservative. It was reported that 14-3-3 proteins were associated with the cardiovascular and cerebrovascular diseases, neuron protection, Parkinson's disease, bronchial asthma, and so on. In recent years, more and more studies focus on the relationship between 14-3-3 proteins and cancers. 14-3-3 Proteins were involved in multiple common cancers such as liver cancer, lung cancer, nasopharyngeal carcinoma, esopha-geal cancer, gastric cancer, breast cancer, colorectal cancer, etc. The effects of 14-3-3 proteins on proliferation , metastasis, apoptosis, and resistance of cancer cells had been confirmed and a part of mechanisms had been elucidated. The family of mammalian 14-3-3 protein has 7 isoforms :β,ε,γ,η,θ,T and ξ ( σ ) . Different 14-3-3 isoforms display different tissue localization and function. In this article, the activities of 14-3-3 isoforms in different tumor cells were summarized. The possible regulatory mechanisms of 14-3-3 in cancer were discussed. Clarification of the tissue distribution and function of 14-3-3 isoforms may help us to explore a new effective approach for cancer therapy.关键词
14-3-3蛋白家族/亚型/癌症/标志物Key words
14-3-3 protein family/ isoforms/ neoplasms/ marker引用本文复制引用
吕德官..蛋白14-3-3蛋白亚型与癌症[J].国际病理科学与临床杂志,2011,31(5):424-429,6.基金项目
国家自然科学基金(30901577) （30901577）
湖南省高校创新平台开放基金(10K051).This work was supported by National Natural Science Foundation of China (30901577) and the Innovation Platform Open Funds for Universities in Hunan Province,P.R.China (10K051). （10K051）
