中国实用内科杂志2011，Vol.31Issue(11)：853-855,3.
异基因造血干细胞移植后感染的经验性治疗分析
Analyses of empirical anti-infective therapy post-allo-HSCT
沈建良 1宫立众 1刘代红 2黄晓军2
作者信息
- 1. 海军总医院血液科,北京100048
- 2. 北京大学血液病研究所,北京100044
- 折叠
摘要
Abstract
Objective To understand the status of empirical anti-infective therapy post-allo-HSCT and factors related to anti-infective efficacy. Methods The characteristics of anti-infective therapy in each episode and factors related to anti-infective efficacy in 105 infection cases after hematopoietic reconstruction post-allo-HSCT were analyzed retrospectively. Results Range of the anti-infective agents in each episode was 5 ~ 7 d. There was no significant difference in response rate among these episodes (P > 0. 05 ). 82% of responders were proven in first two episodes. Response rates between one-species and two-species group were not different significantly (P > 0.05), but they were higher than that in three-species group in second and later episodes (P < 0.05). Anti-fungal therapy was performed in 59% of cases and lasted two or more episodes in 61. 3% of anti-fungal cases. Accumulated response rate of anti-infective therapy was not associated with graft-versus-host disease, immunosuppressor and the type of transplantation (P > 0.05). Conclusion The first two episodes of anti-infective therapy were crucial for infection cases post-allo-HSCT. After the first episode the wide-overlay treatment of anti-infective agents predicted poor prognosis. Accumulated response rate of anti-infective therapy was not related to graft-versus-host-dis-ease, immunosuppressor and the type of transplantation.关键词
异基因造血干细胞移植/感染/节段/经验性抗感染治疗Key words
allo-HSCT/infection/episode/empirical anti-infective therapy分类
医药卫生引用本文复制引用
沈建良,宫立众,刘代红,黄晓军..异基因造血干细胞移植后感染的经验性治疗分析[J].中国实用内科杂志,2011,31(11):853-855,3.
