摘要
Abstract
Objective To discuss the relationship between the clinical and pathological features and prognosis of children with Henoch-schonlein purpura nephritis (HSPN ). Methods Clinical and pathological records of 55 patients with HSPN, who were admitted to the People' s Hospital of Xinjiang Vigur Autonomous Region from January 2000 to Octomber 2008, were retrospectively collected and analyzed. Results Hematuria with proteinuria was 22 cases (40.0% ) , nephritic syndrome was 16 cases (29.1%) .while simple hematuria or proteinuria, acute glomerulonephritis and rapidly progressive glomerulonephritis were respectively 6 cases (10.9%) ,4 cases (7.3%) and 1 case( 1.8%). The pathologic features were mesangical proliferation, glomerulosclerosis and crescent formation. According to the standard of ISKDC, the majority of pathological changes of HSPN were grade II and grade HI , respectively 27 cases (49.1% ) and 16 cases (29.1% ).The type of clinical manifestation was associated with pathological classification (P < 0.05). The more serious clinical manifestations was, the more severe pathological classifications and their prognosis were. Prognosis was associated with pathological classification (P < 0.05). The more serious pathological classifications were, the more severe their prognosis were. Pathological changes in nepheic tubule and interstitium were associated with pathological classification (P < 0.05).The more serious pathological changes in nepheic tubule and interstitium were, the more severe their prognosis was, and their prognosis also became worse. Conclusion In 55 children with HSPN, the longterm outcomes are closely consistent with the clinical and pathological classification. Serious clinical manifestations and pathological classifications in HSPN usually suggest poor prognosis.关键词
紫癜性肾炎/临床/病理/预后/儿童Key words
Henoch-schonlein purpura/ clinic/ pathology/prognosis/ children分类
医药卫生
