湖北医药学院学报2011，Vol.30Issue(5)：471-474,479,5.
IL-18基因启动子-607C/A位点多态性与冠心病关系的研究
Study on the Correlation Between Interleukin(IL)-18 gene Promoter-607 A/C Polymorphism and Risk of CHD
摘要
Abstract
Objective To investigate the correlation between interleukin( IL)-18 gene promoter-607 A/C polymorphism and the risk of CHD in Chinese Han population. Methods The single nucleotide polymorphism at the position of interleukin (IL)-18 gene promoter -607 A/C were detected by sequence specific priroer-polymerase chain reaction (SSP-PCR) in 141 patients with CHD and 240 healthy controls. The genotype and allele frequencies were analyzed in both CHD group and control group. Meanwhile,the blood lipids were measured by enzyme method. Results In CHD group and control group,the CC, CA.AA genotype frequencies of IL-18 gene promoter-607C/A were 33.3% ,50.4% ,16.3% and 21.3% ,51.3% ,27.4%, respectively;the C,A allele frequencies were 58.5% ,41.5% and 46.9% ,53.1% ,respectively. The frequency of genotype CC and allele C at position -607 C/A of CHD group were significantly higher than those of control group( x2 = 4.56, P = 0. 03 and x2 =7.49, P=0.01 .respectively). Conclusion The CC genotype of IL-18 gene promoter -607 C/A polymorphism may contribute to the susceptibility of CHD in Chinese Han population,and allele C may be a genetic risk factor of CHD.关键词
白细胞介素18/冠心病/单核苷酸多态性Key words
Interleukin 18/Coronary heart disease/Single nucleotide polymorphism分类
医药卫生引用本文复制引用
朱名安,吕军,宋惠,刘兴晖,朱静..IL-18基因启动子-607C/A位点多态性与冠心病关系的研究[J].湖北医药学院学报,2011,30(5):471-474,479,5.基金项目
湖北省教育厅重点项目(2003A012) （2003A012）
