超高效液相色谱-串联质谱法测定鱼组织中的6种抗雌激素药物OA北大核心CSCDCSTPCD
Determination of 6 antiestrogens in fish tissues by ultra performance liquid chromatography-tandem mass spectrometry
采用超高效液相色谱-串联质谱(UPLC-MS/MS)在多反应监测(MRM)模式下建立了鱼肉、鱼肝中6种抗雌激素类药物(托瑞米芬、氯米芬、他莫昔芬、雷洛昔芬、阿那曲唑、来曲唑)的检测方法.样品采用乙腈超声提取,上清液中加入适量水稀释提取液,经混合型阳离子交换(MCX)固相萃取柱富集、净化后进行UPLC-MS/MS分析.UPLC分离在ACQUITY UPLCTM BEH C18柱(100 mm×2.1 mm,1.7 μm)上进行,以乙腈和0.1%甲酸…查看全部>>
A comprehensive analytical method based on ultra performance liquid chromatogra-phy-tandem mass spectrometry ( UPLC-MS/MS ) has been developed for the simultaneous determination of 6 antiestrogens ( toremifene, clomiphene, tamoxifen, raloxifene, anastrozole and letrozole ) in fish muscle and liver. The multi-reaction monitoring mode was employed for the determination. The homogeneous fish tissue samples were ultrasonically extracted with ace-tonitrile, and t…查看全部>>
肖甚圣;杨奕;张晶;吴永宁;邵兵
武汉工业学院食品科学与工程学院,湖北,武汉,430023北京市疾病预防控制中心,食物中毒诊断溯源技术北京市重点实验室,北京,100013北京市疾病预防控制中心,食物中毒诊断溯源技术北京市重点实验室,北京,100013武汉工业学院食品科学与工程学院,湖北,武汉,430023中国疾病预防控制中心营养与食品安全所,北京,100025
化学化工
固相萃取超高效液相色谱-串联质谱抗雌激素药物鱼肉鱼肝
solid phase extraction ( SPE ) ultra performance liquid chromatography-tandem mass spectrometry ( UPLC-MS/MS ) antiestrogens fish muscle fish liver
《色谱》 2011 (11)
1055-1061,7
国家自然科学基金重点项目(No.20837003)和北京市卫生系统高层次卫生技术人才培养计划项目.
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