郑州大学学报（医学版）2011，Vol.46Issue(4)：523-525,3.
河南汉族精神分裂症患者线粒体DNA7445和5178位点突变分析
Analysis of polymorphisms in mitochondrial DNA 7445, 5178 point mutation of schizophrenia
摘要
Abstract
Aim: To investigate the prevalence of mitochondrial ONA ( mtDNA) mutation at position 7445 and S178 C →A in Henan Han patients with schizophrenia( SZ). Methods:296 unrelated SZ patients with schizophrenia and 305 health control individuals without family history of schizophrenia were examined. The presence of mtDNA 7445 and 5178 mutation was determined by polymerase chain reaction amplification and restriction fragment length polymorphism (PCR-RFLP). Finally, mutant mtDNA was confirmed by DNA sequencing. Results:The mtDNA mutation at position 5178 C→A was found in 69 of 305 control individuals ( 20.3% ) , and this mutation was found in 88 of 296 patients with SZ (29.7% ). There was significant difference in respect to the frequency of the mutation between patients and controls (X2 =3.931 ,P =0.047). The mtDNA mutation at position 7445 was not found in any of the patients and controls. Conclusion: The mtDNA mutation at position 5178 C→A is possiblly related to SZ probably. The mtDNA mutation at position 7445 may be not related to SZ.关键词
精神分裂症；线粒体DNA；点突变Key words
schizophrenia/mitochondrial DNA/point mutation分类
医药卫生引用本文复制引用
曹玉媛,张景亮,徐朝阳,程晓丽..河南汉族精神分裂症患者线粒体DNA7445和5178位点突变分析[J].郑州大学学报（医学版）,2011,46(4):523-525,3.基金项目
河南省卫生厅科技基金资助项目 200903006 （）
