郑州大学学报（医学版）2011，Vol.46Issue(4)：526-528,3.
硫化氢延迟预处理对大鼠心肌缺血再灌注损伤后细胞的保护作用
Cytoprotection of hydrogen sulfide delayed preconditioning on myocardial ischemic reperfusion injury in rats
摘要
Abstract
AitT: To observe the cytoprotection of hydrogen sulfide delayed preconditioning on myocardial ischemic reperfusion injury in rats and the possible mechanism. Methods: Thirty-two male SD rats were randomly divided into 4 groups; group sham, IR group (group IR) , hydrogen sulfide treatment group (group H2S) and 5-HD + H2S group (group 5-HD). IR model was made by ligation of the anterior descending coronaryartery for 30 min followed by 120 min reperfusion. We observed myocardial ultrastructure under electron microscope and detected myocardial Bcl-2 and Bax protein by western blotting. Results:The expressions of Bcl-2 and Bax protein among 4 groups were different, there were obvious differences ( F = 31.937 and 11.681 ,P<0.001).The expressions of Bcl-2 protein was higher and Bax protein was lower in group IR than in group H2S(P<0.05) . There was no significant difference in group IR and in group 5-HD(P >0.05). Conclusion: Hydrogen sulfide protect myocardial function. Regulation of cell apoptosis and activating mitoKATP are the possible mechanisms.关键词
硫化氢；缺血再灌注；凋亡；线粒体ATP敏感性钾通道；大鼠Key words
hydrogen sulfide/ischemia reperfusion/apoptosis/mitochondrial ATP sensitive potassium channel/rat分类
医药卫生引用本文复制引用
李双凤,冉珂,王亚平,唐正国,肖艳英,王丹..硫化氢延迟预处理对大鼠心肌缺血再灌注损伤后细胞的保护作用[J].郑州大学学报（医学版）,2011,46(4):526-528,3.基金项目
湖南省卫生厅基金资助项目 B2009110 （）
