中国病理生理杂志2011，Vol.27Issue(12)：2411-2413,2422,4.DOI:10.3969/j.issn.1000-4718.2011.12.034
Treg/Th17失衡在脓毒症发病机制中的作用
Effect of disequilibrium of Treg/Th17 in pathogenesis of sepsis
吴铁军 1张丽娜 1亢翠翠1
作者信息
- 1. 聊城市人民医院ICU,山东,聊城,252000
- 折叠
摘要
Abstract
AIM: To investigate the disequilibrium of regulatory T - lymphocytes( Treg ) T helper 17 cells ( Thl7 ) in sepsis. METHODS: Seventy sepsis patients hospitalized in our ICU during January 2010 to August 2010 were enrolled in the study and divided into sepsis group ( n = 34 ), severe sepsis group ( n = 21 ) and septic shock group ( n = 15 ) based on the severity. Serum samples were collected from all the patients on the first day. The percentages of Thl7 and Treg and HLA - DR expression in CD14 monocytes were determined by flow cytometry. The relationship between ratio of Treg/Thl7, and immune state, pathogenetic severity ( score of APACHE II ) was also investigated. Thirty matched healthy individuals in the hospital for heath examination in the same period of time served as controls. RESULTS: The percentages of Thl7 and Treg were significantly higher in all disease groups than those in control group ( all P < 0. 01 ). The highest percentage of Thl7 was observed in severe sepsis group and the highest percentage of Treg was found in septic shock group. The levels of Treg/Thl7 ranged as septic shock group > severe sepsis group > sepsis group and there was significant difference between every 2 groups ( all P < 0. 01 ). The level of Treg/Thl7 was lower in sepsis group and higher in septic shock group than that in control group ( P < 0. 01 ), and no significant difference between severe sepsis group and control group was observed. The HLA - DR expression levels in CD14 monocytes ranged as septic shock group < severe sepsis group < sepsis group < control group, and there was significant difference between every 2 groups ( all P <0. 01 ). The expression of HLA - DR and score of APACHE II showed no correlation with the percentage of Thl7. The percentage of Treg showed positive correlation with the score of APACHE II ( r =0. 93 , P <0. 01 ) and negative correlation with the expression of HLA- DR ( r = -0. 89, P <0. 01 ). The HLA - DR expression showed negative correlation with the score of APACHE II ( r =- 0.91, P < 0. 01 ). CONCLUSION: The ratio of Treg to Thl7 is abnormal in sepsis patients. The disequilibrium of Treg/Thl7 influences the development, of sepsis. To some extent, the level of Treg reflects the pathogenetic conditions andimmune state of sepsis patients.关键词
脓毒症/休克,脓毒性/Th17细胞/T淋巴细胞,调节性Key words
Sepsis/ Shock, septic/ Thl7 cells/ T-lymphocytes, regulatory分类
医药卫生引用本文复制引用
吴铁军,张丽娜,亢翠翠..Treg/Th17失衡在脓毒症发病机制中的作用[J].中国病理生理杂志,2011,27(12):2411-2413,2422,4.
