摘要
Abstract
Aim: To investigate the clinical and pathological differences between HBV-associated membranous nephropathy ( HBV-MN) and idiopathic membranous nephropathy(IMN) in adults. Methods:Two hundred and seven patients with HBV-MN (n =70) or IMN (n = 137) were enrolled in this study. The clinical and pathological results were compared between the two groups. Results: The mean age of the HBV-MN group was significantly younger than that of IMN group [(31.7±14.0) years vs (47. 1 ± 13. 0) years;t = 3. 533 ,P < 0. 001 ) ]. Mesangial proliferation was more commonly observed in HBV-MN group than that of IMN group(98.6% vs 69.3% ;X2 = 24.048,P < 0.001) ,and immunofluorescence discovery of HBV-MN group was various immune-complex deposition, and the deposition of the immune-complex,IgM ,IgA,C3, Clq(X2 =18.175,21.990,16.448, and 50. 846, P < 0.001 ), FRA(P =0.007) in the renal tissue between these two groups was statistically significant. Conclusion;Clinical features of HBV-MN are similar to those of IMN, but the two groups have their own characteristics in pathology, so the combination of clinical and pathological features is necessary to the diagnosis.关键词
膜性乙肝病毒相关性肾炎；特发性膜性肾病；成人；临床特点；病理特点Key words
HBV-associated membranous nephropathy/ idiopathic membranous nephropathy/ adult/ clinical feature/ pathological feature分类
医药卫生
