郑州大学学报（医学版）2011，Vol.46Issue(4)：604-608,5.
依达拉奉对体外循环心脏手术患者心肌缺血再灌注损伤治疗作用的meta分析
Meta-analysis of effectiveness of edaravone for treatment against ischemic-reperfusion injury in patients undergoing cardic operation with cardiopulmonary by-pass
黄建敏 1杜书章 1张晓坚1
作者信息
- 1. 郑州大学第一附属医院药学部,郑州450052
- 折叠
摘要
Abstract
Aim: To assess the effectiveness of edaravone for treatment against ischemic-reperfusion injury (IRI) in patients undergoing cardie operation with cardiopulmonary by-pass. Methods: The related articles were searched, Pubmed, Highwire Press, EMBASE, WAN FANG DATA.CNKI and China Biological Medcine Database from Apr. 2001 to Jul. 2010.The Revman 5.0 software was used for the meta analysis. ReSUltS:A total of 6 RCT (n =202) were identified. The level of methodology was classified as B. Compared with the control group,in edravone group,there are significant difference in the spontaneous return rates of hearts after aorta declamping was higher (RR = 1.54,95% C/= 1.05 -2.25.P =0.03) ; and also in plasma concentration of MDA( at 2 h,6 h and 24 h after aorta declamping) ,serum concentation of SOD(24 h after surgery operation 95% CI = 0. 47 ~ 1. 18, SMD = 0. 82, P < 0. 001), CK-MB and cTnl ( at 6 h and 24 h after aorta declamping). Conclusion:Edaravone may have some protective effect for the treatment against ischemic-reperfusion injuryin patients undergoing cardiac operation with cardiopulmonary by-pass.关键词
依达拉奉；心肌缺血再灌注损伤；meta分析；体外循环心脏手术Key words
edravone/ cardie ischemic-reperfusion injury/ meta-analysis/ cardie operation with cardiopulmonary by-pass分类
医药卫生引用本文复制引用
黄建敏,杜书章,张晓坚..依达拉奉对体外循环心脏手术患者心肌缺血再灌注损伤治疗作用的meta分析[J].郑州大学学报（医学版）,2011,46(4):604-608,5.
