中国全科医学2011，Vol.14Issue(34)：3936-3939,4.
血清1,25-二羟维生素D3水平与糖尿病肾病的关系研究
Relationship between Serum 1,25-Dihydroxyvitamin D3 and Diabetic Nephropathy
摘要
Abstract
Objective To explore the association of serum 1, 25 - Dihydroxyvitamin D3 level with type 2 diabetes mellitus ( T2DM ) and its role in development of diabetic nephropathy ( DN ) . Methods Totally 64 T2DM patients and 20 healthy subjects were recruited. The patients were further divided as groups of non - albuminuria, micro - albuminuria, poly - albuminuria, and renal insufficiency according to the urinary albumin to creatinine ratio ( ACR ) and serum creatinine level. The level of serum 1, 25 - Dihydroxyvitamin D3 was detected by enzyme linked immunosorbent assay ( ELISA ), and the levels of blood glucose, lipid, glycosylated hemoglobin ( HbA,c ), creatinine, calcium, phosphorus, body mass index, and insulin were measured. Results ( 1 ) The T2DM patients had lower serum 1, 25 - Dihydroxyvitamin D3 levels than healthy subjects and the difference was statistically significant ( P < 0. 05 ). ( 2 ) Serum 1, 25 - Dihydroxyvitamin D3 levels of the four groups were gradually decreased and significant differences were observed ( P <0. 05 ). ( 3 ) Serum 1, 25 - Dihydroxyvitamin D3 levels was negatively correlated with BMI, serum creatinine and HOMA insulin resistance index ( HOMA - IR ) ( P <0. 05 ). Conclusion The level of serum 1, 25 - Dihydroxyvitamin D3 may be associated with type 2 diabetes mellitus and diabetic nephropathy, playing an important role in their procedures.关键词
糖尿病肾病/糖尿病,2型/1,25-二羟维生素D3Key words
Diabetic nephropathies/Diabetes mellitus,type 2/ 1, 25 - Dihydroxyvitamin D3分类
医药卫生引用本文复制引用
谷丽娟,刘建萍,霍亚南,刘精东..血清1,25-二羟维生素D3水平与糖尿病肾病的关系研究[J].中国全科医学,2011,14(34):3936-3939,4.基金项目
江西省卫生厅课题(2009-3008) （2009-3008）
