中国全科医学2011，Vol.14Issue(35)：4114-4116,3.
同时伴有t(8;21)和inv(16)/t(16;16)染色体易位的急性髓系白血病:实验室诊断
Acute Myeloid Leukemia with t (8;21) and inv(16)/t(16;16) Double Chromosome Translocation:Laboratory Diagnosis
胡延平 1张旻昱 1张男 1陈芳 1张振忠 1崔丽芬 1张继红1
作者信息
- 1. 110022辽宁省沈阳市,中国医科大学附属盛京医院血液研究室
- 折叠
摘要
Abstract
Objective To report a rare case with t ( 8; 21 ) and inv ( 16 ) /t ( 16; 16 ) double translocation, and to investigate laboratory features of the case. Methods Bone marrow smears were prepared for morphological analysis and flow cytometric detection; cytogenetics analysis was made by flow cytometry ( FCM ); AML1/ETO and CBFβ/MYH11 fusion transcript were detected by real - time quantitative reverse transcription - polymerase chain reaction ( RQ - PCR ) and fluorescence in situ hybridization ( FISH ). Results Diagnosis from cell morphology was acute M4Eo; Medullary antigen was expressed by FCM; Karyotype was 46, xx, t ( 8; 21 ) ( q22; q22 ) [ 11 ] / 46, xx [ 9 ] by CCA; Fusion genes AML1/ET0 and CBFβ/ MYHllwas positive. Conclusion The laboratory features of the case is of great importance for the research on CBF - AM's Pathogenic mechanism and it also provides laboratory evidence for clinic to perform individualized treatment.关键词
白血病,髓样,急性/染色体/核心结合因子β亚基Key words
Leukemia,myeloid,acute/Chromosome/Core binding factor beta subunit分类
医药卫生引用本文复制引用
胡延平,张旻昱,张男,陈芳,张振忠,崔丽芬,张继红..同时伴有t(8;21)和inv(16)/t(16;16)染色体易位的急性髓系白血病:实验室诊断[J].中国全科医学,2011,14(35):4114-4116,3.
