中国全科医学2011，Vol.14Issue(36)：4133-4135,3.
甲地孕酮对晚期直肠癌患者化疗期间及化疗后生活质量的影响研究
The Effect of Megestrol Acetate on Life Quality of Patients with Advanced Rectal Cancer during Chemotherapy
摘要
Abstract
Objective To observe the assisting effect of megestrol acetate on improving life quality of the patients suffering from advanced rectal cancer during Chemotherapy. Methods 143 cases sufferring from advanced rectal cancer admitted to the first affiliated hospital of Xin Jiang Medical University from June 2007 to December 2010 were cellected, and they were divided into control group treated only by chemotherapy and experiment group treated by chemotherapy combined with MPA. Appetite, weight, toxicum reaction and the whole body change of two groups were observed. Results 47 cases ( 64. 4% ) had an increase on appetite and 42 cases ( 57. 5% ) had an increase on weight in experiment group, while the numbers in control group were 10 cases ( 14. 3% ) and 6 cases ( 8. 6% ) respectively. The differences between the two groups were statistically significant ( P = 0. 0001 ) . 53 cases ( 72. 6% ) improved on KPS in experiment group and 13 cases ( 18. 6% ) improved in control group, the difference between the two groups was statistically significant ( P =0. 0001 ) . The difference of diarrhea incidence between the two groups was not statistically significant ( P = 0. 304 ) . The incidences of nausea and vomit, especially the nausea and vomit from stage Ⅲ to Ⅳ in experiment group were significantly lower than that in control group ( P < 0. 05 ) . The differences in the decrease of haematoglobin, anemia from stage Ⅲ to Ⅳ , recovery time, decrease of leukocyte count, decrease of leukocyte count from stage Ⅲ to Ⅳ and recovery time between the two groups were statistically significant ( P < 0. 05 ) . The differences of platelet count, platelet count from stage Ⅲ to Ⅳ and recovery time between the two groups were not statistically significant ( P >0. 05 ). 31 cases ( 42. 5% ) in experiment group had phalacrosis while 39 cases ( 55.1% ) in control group had phalacrosis, the difference between the two groups was statistically significant ( P < 0. 05 ) . Conclusion Megestrol acetate can reduce gastrointestinal side effects, increase appetite, and improve life quality during chemotherapy in patients with advanced stage rectal cancer.关键词
直肠肿瘤/抗肿瘤联合化疗方案/甲地孕酮/生活质量Key words
Rectal neoplasms/Antineoplastic combined chemotherapy protocols/Megestrol/Quality of life分类
医药卫生引用本文复制引用
艾力江·吐尔逊,帕丽达·阿皮孜,张莉,张建清,杨媚..甲地孕酮对晚期直肠癌患者化疗期间及化疗后生活质量的影响研究[J].中国全科医学,2011,14(36):4133-4135,3.基金项目
国家自然科学基金(30760239) （30760239）
新疆维吾尔自治区自然科学基金(2010211A47) （2010211A47）
