首页|期刊导航|中国神经再生研究（英文版）|Co-culture of astrocytes with neurons from injured brain A time-dependent dichotomy
中国神经再生研究（英文版）2011，Vol.6Issue(35)：2768-2772,5.DOI:10.3969/j.issn.1673-5374.2011.35.008
Co-culture of astrocytes with neurons from injured brain A time-dependent dichotomy
Co-culture of astrocytes with neurons from injured brain A time-dependent dichotomy
摘要
Abstract
As supportive cells for neuronal growth and development, much effort has been devoted to the role of astrocytes in the normal state. However, the effect of the astrocytes after injury remains elusive. In the present study, neurons isolated from the subventricular zone of injured neonatal rat brains were co-cultured with astrocytes. After 6 days, these astrocytes showed a mature neuron-like appearance and the number of survivingneurons, primary dendrites and total branches was significantly higher than those at 3 days. The neurons began to shrink at 9 days after co-culture with shorter and thinner processes and the number of primary dendrites and total branches was significantly reduced. These experimental findings indicate that astrocytes in the injured brain promote the development of neurons in the early stages of co-culture while these cells reversely inhibit neuronal growth and development at the later states.关键词
injured brain/astrocytes/neurons/neural plasticity/neurogenesis/neural regenerationKey words
injured brain/astrocytes/neurons/neural plasticity/neurogenesis/neural regeneration引用本文复制引用
Xiaojing Xu,Min Wang,Jing Liu,Jingya Lv,Yanan Hu,Huanxiang Zhang..Co-culture of astrocytes with neurons from injured brain A time-dependent dichotomy[J].中国神经再生研究（英文版）,2011,6(35):2768-2772,5.基金项目
the National Natural Science Foundation of China,No.30671041,30870642 and 31071220 （）
the Natural Science Founda-tion of Jiangsu Province,No.BK2009119 （）
