首页|期刊导航|中国神经再生研究（英文版）|Chinese herbal extract dl-3n-butylphthalide A commonly used drug for the treatment of ischemic stroke as a novel therapeutic approach to treat neurodegenerative diseases
中国神经再生研究（英文版）2011，Vol.6Issue(35)：2773-2778,6.DOI:10.3969/j.issn.1673-5374.2011.35.009
Chinese herbal extract dl-3n-butylphthalide A commonly used drug for the treatment of ischemic stroke as a novel therapeutic approach to treat neurodegenerative diseases
Chinese herbal extract dl-3n-butylphthalide A commonly used drug for the treatment of ischemic stroke as a novel therapeutic approach to treat neurodegenerative diseases
摘要
Abstract
Dl-3n-butylphthalide is the active component isolated from the seeds of Apium graveolens Linn. A number of pharmacological and clinical studies have proven that dl-3n-butylphthalide is highly po-tent and multi-targeted with low toxicity and has a long time-window for the treatment of ischemic cerebrovascular disease. The mechanisms underlying dl-3n-butylphthalide include improving mi-tochondrial function and microcirculation, inhibiting apoptosis and reducing oxidative stress. Fur-thermore, dl-3n-butylphthalide may also be promising for the treatment of neurodegenerative dis-eases, such as Alzheimer's disease, vascular dementia and Parkinson's disease.关键词
3-n-butylphthalide/ischemic stroke/neurodegenerative diseases/traditional Chinese medicineKey words
3-n-butylphthalide/ischemic stroke/neurodegenerative diseases/traditional Chinese medicine引用本文复制引用
Wenfang He,Wensheng Zhou,Zhiping Hu..Chinese herbal extract dl-3n-butylphthalide A commonly used drug for the treatment of ischemic stroke as a novel therapeutic approach to treat neurodegenerative diseases[J].中国神经再生研究（英文版）,2011,6(35):2773-2778,6.基金项目
the Under-graduate Creative Program of Central South University,No.081053358 （）
the Edu-cation Expenditure of Hunan Provincial Finance Depart-ment,No.2010163 （）
the Key Frontier Research Pro-ject of Central South Univer-sity (from 2010 to 2011) （from 2010 to 2011）
