首页|期刊导航|中国神经再生研究（英文版）|Jiawei Wendan decoction affects mitogen-activated protein kinase signal pathway in the hippocampus of depression rats
中国神经再生研究（英文版）2011，Vol.6Issue(36)：2805-2809,5.DOI:10.3969/j.issn.1673-5374.2011.36.001
Jiawei Wendan decoction affects mitogen-activated protein kinase signal pathway in the hippocampus of depression rats
Jiawei Wendan decoction affects mitogen-activated protein kinase signal pathway in the hippocampus of depression rats
摘要
Abstract
A previous study from our group showed that Jiawei Wendan decoction inhibits protein expression of interleukin-1β, 2, and 6, as well as plasma neuropeptide Y, P substance and somatostatin in the hippocampus of depression rat models. The present study analyzed the influence of Jiawei Wendan decoction on the mitogen-activated protein kinase signal transduction pathway in the hippocampus. Results demonstrated that Jiawei Wendan decoction effectively upregulated expression of small molecular G proteins, extracellular regulated kinase 1/2, and activated ribosomal S6 kinase protein in the rat hippocampus. In addition, Jiawei Wendan decoction exhibits antidepressant effects similar to fluoxetine. The underlying mechanisms were shown to be dependent on increased mitogen-activated protein kinase signal transduction pathway activity.关键词
depression/hippocampus/mitogen-activated protein kinase pathway/neural regeneration/pathogenesis/rats/spleen/stomachKey words
depression/hippocampus/mitogen-activated protein kinase pathway/neural regeneration/pathogenesis/rats/spleen/stomach引用本文复制引用
Liping Zhang,Man Zhang,Li Wu,Meng Xia,Guangbin Li..Jiawei Wendan decoction affects mitogen-activated protein kinase signal pathway in the hippocampus of depression rats[J].中国神经再生研究（英文版）,2011,6(36):2805-2809,5.基金项目
the National Natural Science Foundation of China,No.30973732 （）
