首页|期刊导航|中国神经再生研究（英文版）|Expression of neurocan mRNA and ultrastructure of brain tissue after cerebral ischemia and reperfusion in stroke-prone renovascular hypertensive rats treated by electroacupuncture
Expression of neurocan mRNA and ultrastructure of brain tissue after cerebral ischemia and reperfusion in stroke-prone renovascular hypertensive rats treated by electroacupuncture
Feng Tan Jingbo Sun Saiying Wan Haike Wu Qiwen Huo Jinliang Wang Wenlin Chen Meifeng Fang Xiaolin Liu Xuewen Wang
中国神经再生研究（英文版）2011，Vol.6Issue(36)：2834-2838,5.
中国神经再生研究（英文版）2011，Vol.6Issue(36)：2834-2838,5.DOI:10.3969/j.issn.1673-5374.2011.36.006
Expression of neurocan mRNA and ultrastructure of brain tissue after cerebral ischemia and reperfusion in stroke-prone renovascular hypertensive rats treated by electroacupuncture
Expression of neurocan mRNA and ultrastructure of brain tissue after cerebral ischemia and reperfusion in stroke-prone renovascular hypertensive rats treated by electroacupuncture
摘要
Abstract
We established a stroke-prone renovascular hypertensive rat model by bilateral constriction of the renal artery with sliver loop clips. After ten weeks, middle cerebral artery occlusion was induced for 2 hours. The rats then received electro-acupuncture at Baihui (DU 20) and Dazhui (DU 14) after onset of ischemia for 30 days. In situ hybridization study showed that electroacupuncture significantly reduced the number of neurocan mRNA-positive cells in the ischemic penumbra and hippocampal tissues of rats. Electron microscopy results demonstrated that the structure of neurons and blood vessels in the ischemic tissues were restored with electroacupuncture. Overall, these data suggest that electroacupuncture may protect neurons against ischemic reperfusion injury in stroke-prone renovascular hypertensive rats, which may be regulated by downregulation of expression of nerve inhibitory factor neurocan mRNA.关键词
electroacupuncture/cerebral ischemia and reperfusion/stroke-prone renovascular hypertensive/neurocan mRNA/cellular ultrastructureKey words
electroacupuncture/cerebral ischemia and reperfusion/stroke-prone renovascular hypertensive/neurocan mRNA/cellular ultrastructure引用本文复制引用
Feng Tan,Jingbo Sun,Saiying Wan,Haike Wu,Qiwen Huo,Jinliang Wang,Wenlin Chen,Meifeng Fang,Xiaolin Liu,Xuewen Wang..Expression of neurocan mRNA and ultrastructure of brain tissue after cerebral ischemia and reperfusion in stroke-prone renovascular hypertensive rats treated by electroacupuncture[J].中国神经再生研究（英文版）,2011,6(36):2834-2838,5.基金项目
Research Projects of Science and Technology Bureau of Foshan City,No.04080131 （）
fund by the Administration Bureau of Traditional Chinese Medicine of Guangdong Province,No.1050006 （）
and the Natural Science Foundation of Guangdong Province,No.8152800007000001 （）
