中国全科医学2011，Vol.14Issue(36)：4153-4156,4.
瑞舒伐他汀对颈动脉粥样硬化患者血脂和颈动脉斑块的影响
The Influences of Rosuvastatin on Hyperlipidemia and Carotid Artery Plaques in Patients with Carotid Atherosclerosis
摘要
Abstract
Objective To study the influences of rosuvastatin on lipid level and thickness of plaque in patients with carotid atherosclerosis and to observe its long - term effects on atherosclerosis. Methods 40 patients diagnosed by Color Doppler ultrasound with carotid artery plaque from clinics and medical centers from January 2008 to December 2009 were randomly divided into treatment group and control group, with each group 20 cases. The treatment group was given rosuvastatin 10 mg/d combined with enteric - coated aspirin 75 mg/d. The control group was only given enteric - coated aspirin 75 mg/d. Patients of the two groups were given drugs accordingly to decrease blood pressure and glucose and were given diet controls. Lipid levels, total numbers of carotid artery plaque, plaque thickness and plaque changes of the two groups were observed before treatment and 12 months after treatment, and end points of the two groups were also recorded. Results ( 1 ) In the treatment group, serum TC level was reduced significantly from ( 4. 93 ± 1. 12 ) mmol /L to ( 3. 80 ±0. 98 ) mmol/L, LDL - C level was reduced significantly from ( 3. 80 ± 1. 73 ) mmol/L to ( 2. 38 ± 1. 18 ) mmol/L ( P < 0. 05 ) . HDL - C level and TG level showed no significant change compared with those before the treatment ( P > 0. 05 ) . Indexes of blood lipid in the control group showed no significant change during observing period. ( 2 ) Total numbers of plaques showed no significant change in the treatment group after treatment, while the plaque thickness reduced significantly from ( 1. 92 ± 0. 53 ) mm to ( 1. 10 ± 0. 50 ) mm ( P < 0. 05 ), and 74. 5 % of soft plaques changed into hard plaques. Total numbers of plaques showed no significant change in the control group, while the plaque thickness increased from ( 1. 60 ±0. 37 ) mm to ( 1. 72 ±0. 38 ) mm, and 15. 7% of soft plaques changed into hard plaques. Conclusion ( 1 ) The lipid lowering drug rosuvastatin can reduce TC and LDL levels in hyperlipidemia patients with carotid atherosclerosis. ( 2 ) Rosuvastatin can reduce plaque thickness of hyperlipidemia patients with carotid artery atherosclerotic , and can stabilize plaque in carotid artery.关键词
瑞舒伐他汀/动脉粥样硬化斑块/颈动脉狭窄Key words
Rosuvastatin/Atherosclerosis plaque/Carotid stenosis分类
医药卫生引用本文复制引用
高丽君,齐晓勇,王秀萍,高俊茶,蔺杰..瑞舒伐他汀对颈动脉粥样硬化患者血脂和颈动脉斑块的影响[J].中国全科医学,2011,14(36):4153-4156,4.基金项目
河北省科学技术研究与发展计划项目(08276101D-102) （08276101D-102）
