山西医科大学学报2011，Vol.42Issue(12)：957-961,5.DOI:10.3969/J.ISSN.1007-6611.2011.12.005
缬沙坦、普萘洛尔对大鼠门静脉高压性胃病胃窦黏膜下微循环及其超微结构的影响
Effect of valsartan,propranolol on microcirculation and ultramicrostructure of gastric mucosa in rats with portal hypertension gastropathy
杨保元 1霍丽娟 2林艾花 1黄会芳 2张清 2吴晓宁2
作者信息
- 1. 山西省大同市第五人民医院消化内科,大同,037006
- 2. 山西医科大学第一临床医学院消化科
- 折叠
摘要
Abstract
Objective To investigate the protective effect of valsartan, propranolol and their combination on portal hypertension gas-tropathy( PHG ) in rats. Methods Ninety rats were randomly divided into 5 groups. The rats were gavaged with valsartan 20 mg/kg once a day in valsartan group,and propranolol 22. 5 mg/kg twice a day in propranolol group. The rats were simultaneously given valsartan and propranolol in valsartan + propranolol group by gavage. The rats were given the equal doses of tap water once a day by gavage in normal group and model group. The administration lasted for 15 d. The serum hyaluronic acid( HA) and precollagen Ⅲ ( PC Ⅲ ) were measured. The pyloric antrum was obtained to detect the submucosal vessel areas and its biggest diameter under light microscope and observe the ultramicrostructure under transmission electron microscope. Results Compared with model group,the serum contents of HA and PC Ⅲ decreased in valsartan group and valsartan + propranolol group( P < 0.05 ), and submucosal vessel areas and biggest diameter of submucosa also decreased in valsartan group, propranolol group and valsartan + propranolol group, especially in valsartan + propranolol group(P<0. 01 ). In model group, phlebectasia, varices, tubal wall thinning and leukomonocyte infiltration were observed under light microscope, while phlebectasia and varices were significantly improved in medication groups, especially in combination group. The widened interspace and angiotelectasis were observed under transmission electron microscope in medication groups, but an-giotelectasis was slighter than that in model group. Compared with model group, the damages of cell and chondriosome were improved in medication groups, especially in combination group. Conclusion Both valsartan and propranolol, especially their combination have significant protective effect on gastric mucosa of PHG in rats by lessening submucous angiotelectasis of antrum and improving the blood supply of mucosa. And valsartan can also lessen the liver fibrosis.关键词
缬沙坦/普萘洛尔/门静脉高压性胃病/超微结构/大鼠Key words
valsartan/propranolol/portal hypertension gastropathy/ultramicrostructure/rats分类
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杨保元,霍丽娟,林艾花,黄会芳,张清,吴晓宁..缬沙坦、普萘洛尔对大鼠门静脉高压性胃病胃窦黏膜下微循环及其超微结构的影响[J].山西医科大学学报,2011,42(12):957-961,5.
