首页|期刊导航|中国神经再生研究（英文版）|Oligodendrocyte transcription factor 1 overexpression promotes oligodendrocyte transcription factor 2 expression in the brains of neonatal rats exposed to hypoxia****☆
中国神经再生研究（英文版）2011，Vol.6Issue(34)：2713-2717,5.DOI:10.3969/j.issn.1673-5374.2011.34.011
Oligodendrocyte transcription factor 1 overexpression promotes oligodendrocyte transcription factor 2 expression in the brains of neonatal rats exposed to hypoxia****☆
Oligodendrocyte transcription factor 1 overexpression promotes oligodendrocyte transcription factor 2 expression in the brains of neonatal rats exposed to hypoxia****☆
摘要
Abstract
To examine the expression profiles of oligodendrocyte transcription factors 1 and 2 (Olig1 and Olig2) and the interaction between these two proteins, Olig1 was transfected into the lateral ventricles of neonatal rats subjected to hypoxia. Immunohistochemistry demonstrated that Olig2 was expressed throughout the nuclei in the brain, and expression increased at 3 days following hypoxia and was higher than levels at 7 days following Ad5-Olig1 transfection. Western blot revealed that Olig1 and Olig2 expression increased in Olig1-transfected brain cells 3 days after hypoxia, but Olig1 and Olig2 expression decreased at 7 days. These results indicate that Olig1 overexpression enhances Olig2 expression in brain tissues of hypoxia rats.关键词
oligodendrocyte transcription factor 1/oligodendrocyte transcription factor 2/hypoxia/neonatal rat/gene transfection/neural regenerationKey words
oligodendrocyte transcription factor 1/oligodendrocyte transcription factor 2/hypoxia/neonatal rat/gene transfection/neural regeneration引用本文复制引用
Lijun Yang,Hong Cui,Aijun Yang,Wenxing Jiang..Oligodendrocyte transcription factor 1 overexpression promotes oligodendrocyte transcription factor 2 expression in the brains of neonatal rats exposed to hypoxia****☆[J].中国神经再生研究（英文版）,2011,6(34):2713-2717,5.基金项目
the National Natural Science Foundation of China, No. 30872778/C1704* （）
the Natural Science Foundation of Beijing, No. 7072023* （）
the Clinical Basic Cooperation Foundation of Capital Medi-cal University, No. 2009jl18* （）
the Clinical Basic Coopera-tion Foundation of Capital Medical University, No.11JL-L03* （）
