中德临床肿瘤学杂志（英文版）2012，Vol.11Issue(1)：33-36,4.DOI:10.1007/s10330-011-0903-7
Apogossypolone对人前列腺癌LNCaP移植瘤的生长抑制作用
Inhibitory effects of apogossypolone on subcutaneous implants of human LNCaP prostatic carcinoma cells
Yaozhen Chen 1Haishan Chen 2Chen Chen 1Xiaofeng Huang 3Shijie Mu 1Mengyao Zhang 4Xingbin Hu 1Qunxing An 1Xianqing Zhang1
作者信息
- 1. Department of Blood Transfusion, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China
- 2. Department of Blood Transfusion, 210 Hospital of PLA, Dalian 116000, China
- 3. Central laboratory, The Fourth Military Medical University, Xi'an 710032, China
- 4. Department of Chemistry, School of Pharmacy, The Fourth Military Medical University, Xi'an 710032, China
- 折叠
摘要
Abstract
Objective: The aim of this study was to investigate the inhibitory effect of apogossypolone (ApoG2) on subcutaneous implants of human LNCaP prostatic carcinoma cells, and explore its mechanism. Methods: To establish human LNCaP prostatic carcinoma cell line subcutaneous xenograft models and observe the inhibitory effect of ApoG2 on the tumor model. Immunohistochemistry was employed to observe the expression of Bcl-2, PCNA, CD31, caspase-3 and-8 in tumor tissues. The microvessel density was calculated. Results: ApoG2 could obviously inhibit the growth of subcutaneous prostatic carcinoma implant. ApoG2 decreased the expression of PCNA and CD31, and increased the expression of caspases-3,-8 in tumor tissues. Conclusion: ApoG2 has an inhibitory effect on prostatic carcinoma implants. 关键词
apogossypolone (ApoG2)/ prostate cancer/ LNCaP human prostatic carcinoma cell line/ transplantation Key words
apogossypolone (ApoG2)/ prostate cancer/ LNCaP human prostatic carcinoma cell line/ transplantation 引用本文复制引用
Yaozhen Chen,Haishan Chen,Chen Chen,Xiaofeng Huang,Shijie Mu,Mengyao Zhang,Xingbin Hu,Qunxing An,Xianqing Zhang..Apogossypolone对人前列腺癌LNCaP移植瘤的生长抑制作用[J].中德临床肿瘤学杂志（英文版）,2012,11(1):33-36,4.
