安徽医科大学学报2011，Vol.46Issue(12)：1238-1241,4.
SDF-1α和CXCR4在低氧缺糖海马脑片中的表达变化
Expressional changes of SDF-1α and CXCR4 proteins in oxygen-glucose deprivation hippocampal organotypic slice culture of rat
摘要
Abstract
To investigate expressional changes of SDF-1 α and CXCR4 proteins in oxygen-glucose dep-rivation( OGD ) hippocampal slice. Methods Western blot and immunohistochemistry analyses were used to detect SDF-1 α and CXCR4 proteins expression in hippocampal slice of HOTC group and OGD group. Results Immunohistochemistry showed that the SDF-1 α and CXCR4 proteins were expressed in hippocampal slice both HOTC group and OGD group, its hyalomitome was stained, and the CXCR4 protein expression was detected in the axon hillock of pyramidal cells. Western blot results showed that the expressions of SDF-1 α and CXCR4 proteins increased after OGD, and the expression of SDF-1 a proteins had significantly increased( P <0. 01 ). Conclusion The expressional changes of SDF-1 α and CXCR4 proteins indicate that SDF-1 a is associated with the OGD of hippocampal slice.关键词
SDF-1α/CXCR4/低氧缺糖/脑片培养/大鼠Key words
SDF-1 α/ CXCR4/ oxygen-glucose deprivation/ hippoeampal slice culture/ rat分类
医药卫生引用本文复制引用
王玉兰,徐红,李爱娜..SDF-1α和CXCR4在低氧缺糖海马脑片中的表达变化[J].安徽医科大学学报,2011,46(12):1238-1241,4.基金项目
江苏省高校自然科学研究计划项目(编号:08KJB310013) （编号:08KJB310013）
徐州医学院院长专项人才基金(编号:08KJZ03) （编号:08KJZ03）
