安徽医科大学学报2011，Vol.46Issue(12)：1257-1259,3.
C-反应蛋白在大鼠自体静脉移植动脉化中的作用
Effect of C-reactive protein on autologous vein graft arterial of rat
摘要
Abstract
To discuss if C-reactive protein ( CRP ) involved in vascular remodeling in the process of venous vein graft arterialization. Methods Interfection with CBS3830, enzyme-linked immunosorbent assay ( EL-SIA ) was used to detect the serum levels of CRP. Detected the intima thickness at 1,2 week in each group. Western blot was used to detect the expression of p38, p-p38. Results At 0 ~2 weeks each time point,CRP levels in the model group showed a gradual upward trend, while that in the sham group increased at first, and then decreased, with the significant difference between two groups ( P <0. 05 ). Compared with the sham group and model group, the drug group had significant differences at 1 week and 2 weeks time( P <0. 05 ). Intimal hyperplasia of drug group,compared with the model group has differences ( P <0. 01 ). 1 week later shows the product of p38 and P-p38 expression, drug group was significantly lower than the other two groups ( P < 0. 01 ). Conclusion CRP take part in the autologous vein graft arterial vascular remodeling process; which may not be related with the p38MAPK pathway for CBS3830 does not play a significant inhibiting effect.关键词
p38MAPK抑制剂/静脉动脉化/内膜增生/CRP/p38/静脉桥Key words
p38MAPK inhibitor/ vein arterialization/ vein grafts/ CRP/ p38/ vein-bridge分类
医药卫生引用本文复制引用
周经月,葛建军,赵智伟,邬松,Abendroth D K..C-反应蛋白在大鼠自体静脉移植动脉化中的作用[J].安徽医科大学学报,2011,46(12):1257-1259,3.基金项目
安徽省科技厅重点项目(编号:07020303071) （编号:07020303071）
