安徽医科大学学报2011，Vol.46Issue(12)：1264-1266,3.
EGFR与PI3K/AKT信号通路相关蛋白在非小细胞肺癌组织中的表达及其意义
The role of EGFR and PI3K/AKT signal pathway in non-small cell lung cancer
摘要
Abstract
To explore the role of epidermal growth factor ( EGFR ) and phosphotylinosital 3 kinase/ser-ine threonine protein kinase ( PI3K/AKT ) signal pathway in non-small cell lung cancer( NSCLC ). Methods The immunohistochemical SP method was used to measure the protein expression of EGFR,PI3K and AKT in the 100 cases of NSCLC and normal paracancerous tissues. Results The positive expression rate of EGFR,PI3K and AKT was 13% ,11% and 7% respectively in the normal paracancerous tissues, while the positive expression rate of EGFR, PI3K and AKT in the NSCLC was 63% ,51% and 23% , which showed significant statistical difference( P < 0. 05 ). Conclusion The expression of the EGFR,PI3K and AKT in NSCLC is higher than those in the normal paracancerous tissues, so EGFR may play a key role in its cancerogenesis by activating the down stream pathway of PI3K/AKT in NSCLC.关键词
表皮生长因子受体/磷酸肌醇3激酶/丝氨酸∕苏氨酸蛋白激酶/非小细胞肺癌/免疫组化Key words
EGFR /PI3K/AKT/ non-small cell lung cancer/ immunohistochemical分类
医药卫生引用本文复制引用
倪琛琛,于敏,张志红..EGFR与PI3K/AKT信号通路相关蛋白在非小细胞肺癌组织中的表达及其意义[J].安徽医科大学学报,2011,46(12):1264-1266,3.基金项目
安徽医科大学中青年学术骨干基金[编号:校人字(2009)38] （2009）
