中国中西医结合杂志2011，Vol.31Issue(8)：1044-1050,7.
从针刺太冲穴治疗抑郁症探讨肝经与额叶联系的静息态功能磁共振研究
Correlation between the Liver Meridian and the Frontal Lobe in Depression by Needling at Taichong (LV3): A Resting-state fMRI Study
摘要
Abstract
Objective To explore the mechanism of depression treatment by needling at Taichong (LV3) and the correlation between the liver meridian and the frontal lobe. Methods Forty-two patients with moderate depression at the first attack in line with Diagnostic and Statistical Manual of Mental Disorders (4th ed) by American Psychiatric Association were assigned to the fluoxetine group, the needling + fluoxetine group, and the needling group, 14 in each. The therapeutic course for them all was one month. Resting fMRI scanning was performed before and after treatment using 3.0 T magnetic resonance. Data were analyzed using fractional amplitude of low frequency fluctuations (fALFF). Paired f-test was used for comparison. Correlation analysis was performed in the fALFF images after treatment and Hamilton's depression scale. Results Compared with before treatment, fALFF values in the left frontal lobe (BA6, BA9, BA48), the right frontal lobe (BA4, BA46), the bilateral inferior parietal lobules (BA40, BA48), the precuneus (BA7), the posterior cingutate (BA31), the left occipital lobe (BA17), and the right occipital lobe (BA18) of the needling + fluoxetine group were lowered (P<0.05). fALFF values in the right inferior parietal lobule (BA40) and the right occipital lobe (BA17) of the fluoxetine group were lowered (P< 0.05). fALFF values in the left frontal lobe (BA10), the right frontal lobe (BA45), the left occipital lobe (BA19), the right occipital lobe (BA17), the left precuneus (BA7), and the posterior cingutate (BA31) were lowered in the needling group (P<0.05). Hamilton's depression scale was positively correlated with the fALFF value in the left frontal lobe of the needling +fluoxetine group and the needling group, while Hamilton's depression scale was positively correlated with the fALFF value in the left middle frontal gyms, the left parietal lobe, and the left occipital lobe in the fluoxetine group. Conclusions Combination of needling and antidepressive agents was superior to needling or antidepressive agents alone. Changes of the frontal lobe functions were correlated with the severity of depression. More extensive correlation existed between the liver meridian and the frontal lobe, which might be the antidepressive mechanism of needling Taichong (LV3).关键词
抑郁症/静息态功能磁共振/针刺/额叶/肝经Key words
depression/ resting-state functional magnetic resonance imaging/ needling/ the frontal lobe/ the liver meridian引用本文复制引用
易洋,胡皓,孙娟,徐放明,谢洪武,宋云娥,吕发金,谢鹏,杨德兰,林云,冯伟..从针刺太冲穴治疗抑郁症探讨肝经与额叶联系的静息态功能磁共振研究[J].中国中西医结合杂志,2011,31(8):1044-1050,7.基金项目
重庆市卫生局医学科学技术研究项目(No.2008-2-65) （No.2008-2-65）
