动物营养学报2011，Vol.23Issue(10)：1658-1663,6.DOI:10.3969/j.issn.1006-267x.2011.10.003
宫内发育迟缓对胰腺内分泌功能影响的研究进展
Effect of Intrauterine Growth Retardation on Endocrine Function of Pancreas: a Review
摘要
Abstract
Intrauterine growth retardation (IUGR) increases the risk of perinatal death and metabolic diseases in neonatal period as well as adult life, with multiple births animals more affected. In animal models, IUGR is usually induced by uterine arteries ligation, maternal caloric restriction and maternal protein restriction. Recently, many researches were conducted to study the consequences of IUGR on the endocrine of pancreas. Those studies have shown that IUGR impairs the development, differentiation and proliferation of pancreatic beta cells. In addition, IUGR leads to a decrease in beta cell mass and pancreatic insulin contents, as well as insulin secretion, and consequently induces metabolic diseases in adult life. This paper reviewed the effect of IUGR on the development of endocrine pancreas.关键词
宫内发育迟缓/胰腺/内分泌功能Key words
intrauterine growth restriction/ pancreas/ endocrine function分类
农业科技引用本文复制引用
孔令蕊,王远孝,王恬..宫内发育迟缓对胰腺内分泌功能影响的研究进展[J].动物营养学报,2011,23(10):1658-1663,6.基金项目
国家自然科学基金资助项目(30771569) （30771569）
