Principles of microRNA involvement in human cancers
Principles of microRNA involvement in human cancers
摘要
Abstract
Naturally occurring microRNAs (miRNAs),small non-coding RNAs of 19 to 24 nucleotides (nt),are encoded in the genomes of invertebrates,vertebrates,and plants.miRNAs act as regulators of gene expression during development and differentiation at the transcriptional,posttranscriptional,and/or translational levels,although most target genes are still elusive.Many miRNAs are conserved in sequence between distantly related organisms,suggesting that these molecules participate in essential processes.In this review,we present principles related to the basic and translational research that has emerged in the last decade,a period that can be truly considered the “miRNA revolution” in molecular oncology.These principles include the regulation mechanism of miRNA expression,functions of miRNAs in cancers,diagnostic values and therapeutic potentials Of miRNAs.Furthermore,we present a compendium of information about the main miRNAs that have been identified in the last several years as playing important roles in cancers.Also,we orient the reader to several additional reviews that may provide a deeper understanding of this new and exciting field of research.关键词
MicroRNA/ non-coding RNA/ cancer/ mutation/ biomarkerKey words
MicroRNA/ non-coding RNA/ cancer/ mutation/ biomarker引用本文复制引用
Hui Ling,Wei Zhang,George A. Calin..Principles of microRNA involvement in human cancers[J].癌症（英文版）,2011,30(11):739-748,10.基金项目
Dr.Calin is supported as a fellow by The University of Texas MD Anderson Research Trust,as a research scholar by The University of Texas System Regents,and by the Chronic Lymphocytic Leukemia Global Research Foundation.Work in Dr.Calin ' s laboratory is supported in part by the National Institutes of Health,a Department of Defense Breast Cancer Idea Award,Developmental Research Awards from the Breast Cancer,Ovarian Cancer,Brain Cancer,Multiple Myeloma,and Leukemia Specialized Programs of Research Excellence (SPORE)grants from the National Institutes of Health,a CTT/31-TD grant,a 2009 Seena Magowitz-Pancreatic Cancer Action Network AACR Pilot Grant,and the Amold Foundation.We thank Sue Moreau from the Department of Scientific Publications at The University of Texas MD Anderson Cancer Center for her help with the editing of this manuscript. （SPORE）
