高等学校化学学报2011，Vol.32Issue(9)：1996-2009,14.
超分子化学在药物共晶中的应用
Application of Supramolecular Chemistry on Pharmaceutical Cocrystals
摘要
Abstract
Pharmaceutical cocrystal is a new type of pharmaceutical crystalline state. It is attractive to pharmaceutical scientists because it can provide a number of crystalline states for a given active pharmaceutical ingredient ( API) , in which the physical and chemical properties of the API can be adjusted by pharmaceutical cocrystal. In this review, we address pharmaceutical cocrystals from the perspective of supramolecular chemistry , and present a series of structures of pharmaceutical cocrystals constructed through hydrogen bonding supramolecular synthons, in which the physical and chemical properties(solubility, dissolution, bioavailability, melting point, stability, etc. ) of APIs can be changed by pharmaceutical cocrystal.关键词
超分子化学/药物共晶/氢键/超分子合成子Key words
Supramolecular chemistry/ Pharmaceutical cocrystal/ Hydrogen bond/ Supramolecular synthon分类
化学化工引用本文复制引用
陈嘉媚,吴传斌,鲁统部..超分子化学在药物共晶中的应用[J].高等学校化学学报,2011,32(9):1996-2009,14.基金项目
国家科技重大专项“重大新药创制”(批准号:2009ZX09501-022)资助. （批准号:2009ZX09501-022）
