高等学校化学学报2011，Vol.32Issue(9)：2128-2132,5.
新型[12]aneN3衍生物的合成及对磷酸二酯的催化降解
Synthesis of New [12]aneN3 Compounds and Their Catalytic cleavage of Phosphodiester
摘要
Abstract
Two new methyl 3,5-dimethylbenzolate derived [12] aneN3 compounds 4a and 4b were prepared through high efficient click reactions and characterized with element analysis, NMR, IR and high resolution MS. The corresponding zinc( II ) complexes can greatly promote the cleavage of RNA model phosphodiester 2-hydroxypropyl4-nitrophenylphosphate( HPNPP) in methanol with an acceleration of 107-fold relative to the background reaction.关键词
人工核酸酶/大环多胺/磷酸二酯/Click反应/锌(Ⅱ)配合物Key words
Artificial nuclease/ Macrocyclic polyamine/ Phosphodiester/ Click reaction/ Zinc( II ) complex分类
化学化工引用本文复制引用
郭治佛,闫浩,李志芬,芦忠林..新型[12]aneN3衍生物的合成及对磷酸二酯的催化降解[J].高等学校化学学报,2011,32(9):2128-2132,5.基金项目
国家自然科学基金(批准号:20972019)和高校博士点新教师基金(批准号:273911)资助. （批准号:20972019）
