中国农业科学2011，Vol.44Issue(19)：4102-4109,8.DOI:10.3864/j.issn.0578-1752.2011.19.022
氟苯尼考双混悬型乳剂的体外药效学研究
Studies on Pharmacodynamics in vitro of the Florfenicol Dual Suspension Emulsion
摘要
Abstract
[Objective] The in vitro pharmacodynamics characteristics of florfenicol dual suspension emulsion (DSEF) were studied in an experiment. [Method] The florfenicol injection (FI) was used as the control group and five kinds of bacteria were used for in vitro antibacterial test to determine the minimal inhibitory concentration (MIC), minimal bactericide concentration (MBC) and mutant selection window (MSW), respectively. The S.typhimurium was used for in vitro antibacterial test about post-antibiotic effect (PAE) and post-antibiotic sub-MIC effect (PASME), respectively. [Result] Compared with the ordinary injection, the MIC and MBC of DSEF for five kinds of bacteria showed no change obviously. But DSEF narrowed MSW obviously of five kinds of bacteria (p<0.01) and extended the PAE and PASME significantly of 5. Typhimurium (p<0.01). [Conclusion] DSEF could reduce the bacterial resistance risk and extend the time of its after effect obviously, thereby improved the antibacterial effect.关键词
氟苯尼考/双混悬型乳剂/体外药效学Key words
florfenicol/dual suspension emulsion(DSE)/pharmacodynamic in vitro引用本文复制引用
李孝文,董伟,杨昆,陈小军,刘兆颖,孙志良..氟苯尼考双混悬型乳剂的体外药效学研究[J].中国农业科学,2011,44(19):4102-4109,8.基金项目
科技部应用技术研究与开发火炬计划基金(2009GJD20048) （2009GJD20048）
湖南省科技重大专项(2009FJ1005) （2009FJ1005）
湖南省科技厅重点项目(2008NK2007) （2008NK2007）
