中国畜牧兽医2011，Vol.38Issue(9)：235-237,3.
复方中药制剂的抗炎及毒性作用检测
Test on the Anti-inflammatory Action and the Toxic Effect of Chinese Herbal Medicine Prescription
摘要
Abstract
The methods of mice ear-swelling and granulation tissue hyperplasia of mice induced by tampon were adopted to study the anti-inflammatory action of pure traditional Chinese herbal medicine for dairy cow mastitis,and improved Karbr was adopted to study the toxic effect of the Chinese herbal medicine prescription with LD50 as the evaluate index of the acute toxicity strength. The test results indicated that the Chinese herbal medicine prescription to mice ear swell were 10. 41,9. 26,8. 82 mg, respectively in the three test groups (high dosage, middle dosage and low dosage of the prescription). There had significant difference between the control group(12. 52 mg) and test groups(P<0. 05). Mice granulation tissue hyperplasia in the Chinese herbal medicine prescription groups were 11. 21,10. 71,8. 83 mg, respectively. There had significant difference between the control group (12. 63 mg) and test groups(P<0. 05). In the actute toxicity test,none mouse was dead,so the LD50 of the prescription were more than 60000 mg/kg·Bw. The results showed that the anti-inflammation action of the Chinese herbal medicine prescription was significantly effective for both of active and chronic inflammation period. The Chinese herbal medicine prescription belongs to a practical innoxious substance and can be used in the clinical research.关键词
中药/小鼠/抗炎试验/急性毒性试验Key words
Chinese herbal medicine/mice/ anti-inflammatory test/ acute toxicity test分类
农业科技引用本文复制引用
冯升,杨康龙,佟丽,孙延鸣..复方中药制剂的抗炎及毒性作用检测[J].中国畜牧兽医,2011,38(9):235-237,3.基金项目
国家大学生创新性实验计划项目资助(091075922). （091075922）
