中国畜牧兽医2011，Vol.38Issue(10)：68-73,6.
H-Y抗原候选基因的研究进展
Progress on Candidate Genes for H-Y Antigens
摘要
Abstract
Male specific minor histocomp atibility (H-Y) antigens are encoded by genes on the Y-chromosome. Generally, the minor H-Y antigens are ubiquitously expressed in male cells including fetal and trophoblast cells. It causes rejection of male tissue grafts by genotypically identical female mice and contributes to graft rejection or graft-versus-host (GVH) disease after HLA-identical stem cell transplantation. Cytotoxicity lymphocytic cells detected several distinct H-Y epitopes, and these are probably peptides, derived from intracellular protein, that are presented at the cell surface with major histocompatibility complex molecules. Processed peptide fragments of the H-Y proteins bind to HLA class I and class [I molecules and are presented to the immune system, and finally their possible impact on the outcome of transplantation. In recent years , more and more studies of the H-Y antigen were reported in the research. This review reflects some candidate genes of encoding male-specific histocompatibility antigen, and the foregrounds of the research in human and diseases are prospected.关键词
H-Y抗原/候选基因/抗原肽Key words
H-Y antigens/candidate genes/antigen peptides分类
农业科技引用本文复制引用
谭庆辉,王乃东,薛立群..H-Y抗原候选基因的研究进展[J].中国畜牧兽医,2011,38(10):68-73,6.基金项目
国家自然辩学基金(30901090/C120209) （30901090/C120209）
湖南省教育厅科学研究优秀青年项目(09B046). （09B046）
