基础医学与临床2011，Vol.31Issue(12)：1402-1405,4.
DNA错配修复和临床肿瘤新进展
The news for MMR and clinical cancer
马守成 1赵达1
作者信息
- 1. 兰州大学第一医院肿瘤内,甘肃兰州730000
- 折叠
摘要
Abstract
DNA replication is an extraordinarily faithful process, mutation occures at a frequency of 1/10 or 1/10 base pairs per cell division. The MMR pathway, a DNA repair pathway conserved from bacteria to humans, targets base substitution mismatches and insertion-deletion mismatches that arise as a result of replication errors that escape the proofreading function of DNA polymerases. In doing so, MMR contributes an additional 50 ~ 1000-fold to the o-verall fidelity of replication. Thus, inactivation of MMR confers a strong mutated phenotype in which the rate of spontaneous mutation is greatly elevated,such as microsatellite stability (MSI) , or mutated genes that code functional proteins, thus give rise to cancer.关键词
DNA错配修复/微卫星不稳定性/结直肠肿瘤/乳腺肿瘤/前列腺肿瘤/神经胶质瘤Key words
DNA MMR/ MSI/ HNPCC (CRC)/ breast cancer/ piwstate cancer Glioma分类
生物科学引用本文复制引用
马守成,赵达..DNA错配修复和临床肿瘤新进展[J].基础医学与临床,2011,31(12):1402-1405,4.
