四川医学2011，Vol.32Issue(11)：1721-1723,3.
托特罗定联合膀胱训练治疗女性膀胱过度活动症
Comparison of tolterodine with bladder training versus tolterodine alone for the trea~nent of women with overactive bladder syndrome
何昌孝 1黄颖川 1王翰辉 1李冬 1袁正勇1
作者信息
- 1. 都江堰市人民医院泌尿外科,四川都江堰611830
- 折叠
摘要
Abstract
Objective Overactive bladder (OAB) is chronic condition that significantly affect quality of life in patients. The goal of treatment of OAB is to improve the lower urinary tract symptoms ( LUTS) and enhance the quality of life. This study aims to investigate whether tolterodine combined with bladder training is more effective than tolterodine alone in the treatment of women with overactive bladder (OAB) , advancing the management of OAB via a prospective review of 219 female cases with OAB symptoms. Methods After we excluded other causes for storage symptoms, 219 consecutive female patients with OAB were pro-spectively studied, of which 110 cases were given tolterodine alone while the other 109 cases were given tolterodine combined with bladder training for the treatment of OAB. Data on urgency, incontinence, micturition frequency, nocturia episodes and voided volume were collected before and after 4 weeks' treatment using a 3-day micturition diary. Results The two groups of OAB patients were given toterodine alone, toterodine combined with bladder training for 4 weeks respectively. At weeks 4, the number of urgency episodes per 24 hours in the intervention group decreased by 2. 5 ( -38. 5% ) , incontinence episodes by 1. 5 ( -75% ) , micturitions by 2.9 (-29%), nocturia episodes by 2 (-57. 1%) and the volume voided per micturition increased by 60ml (36. 4% ) , while in the control group the number of urgency episodes per 24 hours decreased by 1. 5 (-25% ) , incontinence episodes by 0. 8 ( -36. 4% ) , micturitions by 1. 8 ( -15% ) , nocturia episodes by 0. 8 (-26.1% ) and the volume voided per micturition increased by 35ml (22. 2% ). The differences of changes of LUTS between the 2 groups has statistical significance (P < 0. 05 ) . Conclusion A combination of toterodine and bladder training is a potential therapy for female patients with OAB, improving significantly the OAB symptoms.关键词
托特罗定/膀胱训练/膀胱过度活动症/女性Key words
tolterodine/ bladder training/ overactive bladder/ women分类
医药卫生引用本文复制引用
何昌孝,黄颖川,王翰辉,李冬,袁正勇..托特罗定联合膀胱训练治疗女性膀胱过度活动症[J].四川医学,2011,32(11):1721-1723,3.
