应用化学2011，Vol.28Issue(10)：1114-1121,8.DOI:10.3724/SP.J.1095.2011.00699
淀粉基荧光微球的制备及其布洛芬包载和释药性能
Preparation and Drug-release Properties of Ibuprofen-loaded and Fluorescein-labeled Starch-based Nanospheres
摘要
Abstract
Starch was firstly acylated by acetic anhydride, fluorescein isothiocyanate ( FITC) was then covalently attached onto the starch acetate. And the fluorescein-labeled starch acetate could self-assemble to form uniform nanospheres encapsulated with ibuprofen. The controlled-release properties of obtained ibuprofen-loaded fluorescein-labeled starch nanospheres were investigated in details. The amounts of drug-loading and release rate could be tuned by changing the amounts of fluorescein-labeled starch acetate, ibuprofen and volume ratio of acetone to water. The results showed that up to 69. 5% of the drug could be encapsulated when the amounts of fluorescein-labeled starch acetate and ibuprofen were 200 mg and 60 mg, and the volumes of water and acetone were 50 mL and 20 mL, respectively. The drug release rate in vitro of these nanospheres was 62. 7% at 48 h. Moreover, the release process in vitro of the drug-loaded nanospheres was characterized by scanning electron microscope(SEM) and confocal laser scanning microscope(CLSM).关键词
淀粉/荧光微球/布洛芬/包封率/体外释放Key words
starch,fluorescein nanosphere,ibuprofen,encapsulation efficiency,drug release分类
化学化工引用本文复制引用
李洋,宁志刚,谭颖,孙淑苗,王丕新..淀粉基荧光微球的制备及其布洛芬包载和释药性能[J].应用化学,2011,28(10):1114-1121,8.基金项目
国家自然科学基金资助项目(21004065,51073153) （21004065,51073153）
