环境与职业医学2011，Vol.28Issue(11)：672-674,3.
上海青浦区新生儿乙型肝炎疫苗免疫效果及低、无应答者再免疫效果
Effectiveness of Hepatitis B Vaccine Immunization on Infants and Reimmunization on Low- and NonResponders in Qingpu District, Shanghai
摘要
Abstract
[ Objective ] To study the infants1 basic responses to hepatitis B vaccination and the influencing factors in Qingpu District of Shanghai and probe the responses to re-vaccination of diose who showed no or low response in the prior. [ Methods ] * With simple random sampling, a total of 677 infants, who were bom from February 1, 2008 to March 30, 2009 in Qingpu District of Shanghai and vaccinated with 5 μg recombinant beer yeast-derived hepatitis B vaccines (YDVs) or 10μg Hansenula YDVs according to the 0-1-6 immunization schedule, were enrolled as the study subjects. The antibody to hepatitis B surface antigen (anti-HBs) was detected by chemiluminescence microparticle immuno assay. Questionnaires were also employed among the parents to investigate the birth and vaccination course. [ Results ] Of all the 677 infants enrolled, the response rate of the first-course immunity was 82.72%, and the low/non-response rate was 17.28% (2.22% non-response and 15.07% low-response). The group vaccinated with 10 μg Hansenula YDVs showed a higher response rate than the group accepted 5 ug beer YDVs. Logistic regression analysis showed a higher response rate in the infants who were female, vaccinated with Hansenula YDVs or full-term (OR=1.529, 3.617 or 9.356, respectively). Among those who showed no or low response after the first course of vaccination, the response rate of the first and the third shots in the second course vaccination were 91.40% and 94.50% respectively. The response rates of the first and the third shots in the second course of vaccination were obviously higher than that in the first course (P<0.05). [ Conclusion ] The infants who received a full course of the hepatitis B vaccination showed a higher response rate of anti-HBs, but there were still 17.28% of them showed low/non-response. Premature birth, low dosage of vaccine inoculated and mothers with positive hepatitis B surface antigen (HBsAg) are the risk factors for low/non-response. Such infants should be re-vaccinated with another 10μg of Hansenula YDVs.关键词
乙型肝炎疫苗/免疫/新生儿/应答率/再免疫Key words
hepatitis B vaccine/ immunization/ infants/ response rate/ reimmunization分类
医药卫生引用本文复制引用
潘引君,邵杏芳,李燕婷,黎健,费金花,段蓉,潘俊锋,魏延..上海青浦区新生儿乙型肝炎疫苗免疫效果及低、无应答者再免疫效果[J].环境与职业医学,2011,28(11):672-674,3.基金项目
国家“十一五”科技重大专项(编号:2008ZX 10002-001) （编号:2008ZX 10002-001）
