安徽农业科学2011，Vol.39Issue(26)：15965-15967,3.
几种辅料对紫杉醇脂质体粒径及Zeta电位的影响
Effect of Several Materials on the Particle Size and Zeta Potential of Tax Liposome
侯巍 1王淑君 2孙宽 2王敏 1王东星 3刘巍巍4
作者信息
- 1. 沈阳药科大学中药学院,辽宁沈阳110016
- 2. 沈阳药科大学药学院,辽宁沈阳110016
- 3. 沈阳药大药业有限公司,辽宁沈阳110023
- 4. 沈阳格林制药有限公司,辽宁沈阳110164
- 折叠
摘要
Abstract
[Objective] To identify the effect of several materials on the particle size and Zeta potential of Tax liposome 1. [ Method] Tax lipo some was prepared with film dispersion - ultrasound method,the orthogonal experiment was adopted to screen out the optimum formulation of Tax liposome, and detect the particle size and Zeta potential of Tax liposome. [Result] The particle size and stability of liposome was significantly in fluenced by the materials such as eunatrol,and with the increasing amount of those materials,the particle size of liposome became small,Zeta po tential value decreased,while the stability improved. [Conclusion] Materials like eunatrol could significantly decrease the particle size and Zeta potential of Tax liposome,the Tax liposome prepared with the optimum technology had high entrapment efficient,even particle size and good sta bility.关键词
紫杉醇/脂质体/正交设计:粒径/Zeta电位Key words
Paclitaxel/ liposomes/ Orthogonal design/ Partical size/ Zeta potential分类
医药卫生引用本文复制引用
侯巍,王淑君,孙宽,王敏,王东星,刘巍巍..几种辅料对紫杉醇脂质体粒径及Zeta电位的影响[J].安徽农业科学,2011,39(26):15965-15967,3.
