农药学学报2011，Vol.13Issue(5)：519-524,6.DOI:10.3969/j.issn.1008-7303.2011.05.14
渔用氟苯尼考缓释药丸的制备及性能测定
Manufacture and characteristics of antibiotic florfenicol pill with slow-releasing property in fishery
摘要
Abstract
A slow-releasing antibiotic pill was manufactured, in which polylactice acid ( PLA) and starch(20:1 ,m/m) were used as substrate and florfenicol,a broad spectrum antibiotic in fishery,was used as a model of drug. The physical properties, drug release characteristics and biodegradability of the pills were tested using scanning electron microscopy ( SEM ), infrared spectroscopy, ultraviolet spectrometer,etc. The results showed that the drug carrier displayed a porous internal structure with good pore connectivity and high porosity (72.5% ±1.2%), which is beneficial for florfenicol to be distributed evenly inside the whole pill. The drug demonstrated slowly releasing property due to the degradation of substrates' I. E. (0. 28 ±0. 02) or (0. 42 ± 0. 03) mg/L after pills floated on or immersed in sea water for 96 h. The experiments about drug-residue, toxicity of PLA and drug releasing pattern were performed in Xiangshan fishery, Ningbo, Zhejiang Province, using pseudosciaena crocea with weight of ~ 500 g as testing fish In vivo. The result showed that the pills prepared from our present protocol were suitable to be used in fishery cage culture with no obvious toxicity and controlled-releasing.关键词
氟苯尼考/缓释药丸/聚乳酸/缓释性能Key words
florfenicol/ antibiotic pill/ poly lactic acid/ slow-release property分类
化学化工引用本文复制引用
陈哲昕,竺亚斌,徐鑫,王国良..渔用氟苯尼考缓释药丸的制备及性能测定[J].农药学学报,2011,13(5):519-524,6.基金项目
国家自然科学基金(30870645) （30870645）
浙江省杰出青年团队项目(R2101166) （R2101166）
国家农业部公益性行业(农业)科研专项(200903029). （农业）
