中国组织工程研究与临床康复2011，Vol.15Issue(44)：8171-8174,4.DOI:10.3969/j.issn.1673-8225.2011.44.001
恒河猴移植肝组织内细胞间黏附分子1与急性排斥反应的关系
Interrelations between acute rejection and intercellular adhesion molecule-1 in liver tissue after liver transplantation in Rhesus monkey
摘要
Abstract
BACKGROUND: Intercellular adhesion molecuIe-1 (iCAM-1) level in transplanted tissue would increase when acute rejection occurs. OBJECTIVE: To investigate the relationship between ICAM-1 and acute rejection of liver transplantation In Rhesus Monkey. METHODS: Allogenic liver transplantation models were established in Rhesus monkey and then randomly divided into an experimental group (without anti-rejection management after liver transplantation) and a control group (with and-rejection management during and after liver transplantation).RESULTS AND CONCLUSION: At 24 and 72 hours after liver transplantation, serum alanine aminotransferase and serum total bilirubin levels were significantly higher in the experimental group than In the control group (P < 0.05 or P< 0.001). At 12 hours after liver transplantation, transplanted liver in the experimental group showed mild acute rejection, indicating that during acute rejection, liver function changes occur after pathological examination of liver tissue At 24 and 72 hours after liver trans pi ants lion, moderate and severe acute rejection occurred. At 6 hours after liver transplantation, ICAM-1 expression in the vascular endothelisl cells, liver cell membrane, and biliary epithelial cells was significantly increased in the experimental group than in the control group (P < 0.05). In the experimental group, with ICAM-1 expression increasing, rejection was aggravated, indicating that at the early stage of acute rejection, slight changes in liver function and pathological manifestation were observed, and ICAM-1 level was greatly increased. These findings suggest that detection of ICAM-1 level in the calls of transplanted liver tissue would be of significance for early diagnosis of acute rejection after liver transplantation.关键词
细胞间黏附分子1/肝移植/急性排斥反应/细胞间黏附分子1/灵长类动物/恒河猴分类
医药卫生引用本文复制引用
冉江华,张升宁,刘静,李铸,吴淑媛,李来邦,张熙冰,张鸿青,李立..恒河猴移植肝组织内细胞间黏附分子1与急性排斥反应的关系[J].中国组织工程研究与临床康复,2011,15(44):8171-8174,4.基金项目
昆明市科技局重大项目(08S100304). （08S100304）
