中国组织工程研究与临床康复2011，Vol.15Issue(44)：8355-8360,6.DOI:10.3969/j.issn.1673-8225.2011.44.047
穿孔素基因及蛋白功能研究进展
Research progress in perforin gene and protein function
摘要
Abstract
BACKGROUND: Perforin-dependent granule mediated cytolysis is one of major pathways of cell-mediated cytotoxicity. Recently,perforin gene mutation has been found to be related to lymphoproliterative disease.OBJECTIVE: To summarize the research progress in perforin gene, elucidate the relationship between perforin gene mutation andprotein expression, and further investigate the relationship between perforin gene mutation and lymphoproliferative disease.METHODS: A computer-based retrieval was performed to search manuscripts describing the mechanism underlyingdrug-tolerance of bacterial biomembrane published between January 1998 and December 2008 in CNKI and PubMed databaseswith the key words"perforin. Gene, mutation, lymphoprol iferative disease" in Chinese and English languages. Manuscripts withcontents similar to perform gene mutaiion and those published recently or in high-impact journals were selected. A total of 285papers were initially retrieved, and 65 of which were included in the final analysis.RESULTS AND CONCLUSION: Mutations in perforin gene result in the decrease or absence of perforin protein and its activity, sothat immunologies! Surveillance to virus-infected and transformed tumor cells is compromised and lymphoprol iferative diseaseeven cancer may occur. A further understanding of perforin gene mutation and protein expression would help elucidate therelationship between perforin gene mutation and lynhoproliferative disease.关键词
穿孔素/蛋白表达/基因/突变/淋巴细胞增殖病分类
医药卫生引用本文复制引用
赵怡雯,杨丽云,崔娟红..穿孔素基因及蛋白功能研究进展[J].中国组织工程研究与临床康复,2011,15(44):8355-8360,6.
