中国药业2011，Vol.20Issue(23)：4-6,3.
网孔型纳米羟基磷灰石/聚酰胺66复合血管内皮细胞生长因子缓释微球治疗早期股骨头缺血坏死的实验研究
Nano-Hydroxyapatite/Polyamide 66 Biocomposites Combined with Vascular Endothelial Growth Factor for Treating Early Avascular Necrosis of Femoral Head
摘要
Abstract
Objective To observe the effect of porous n-HA/PA66 rods combined with vascular endothelial growth factor(VEGF) for the treatment of early stage avascular necrosis of femoral head in rabbits. Methods Implant n - HA/PA66 supporting stick and VEGF micro-capsule into the rabbit models of ischemic necrosis of femoral head. Results were evaluated by radiograph and histology at the end of 3rd, 6th and 12th week after operation. Results There is no significant difference of radiograph after combination of VEGF. More cancellous bone grew into cage in the group combined with VEGF through staining observation. Conclusion It shows that the composite of VEGF is active in new bone formation and vascular remodeling.关键词
血管内皮细胞生长因子/纳米羟基磷灰石/聚酰胺66/股骨头缺血坏死/骨修复Key words
vescular endothelial growth factor/ nano-hydroxyapatite/polyamide 66/ avascular necrosis of femoral head/ bone repair分类
医药卫生引用本文复制引用
陈诚,梁熙,黄伟,胡宁,尹世杰,杨明明..网孔型纳米羟基磷灰石/聚酰胺66复合血管内皮细胞生长因子缓释微球治疗早期股骨头缺血坏死的实验研究[J].中国药业,2011,20(23):4-6,3.基金项目
重庆市自然科学基金,项目编号:CSTC2007BB5291. （）
