摘要
Abstract
Objective To evaluate the effectiveness and safety of nimesulide comparing with aspirin and aminopyrine. Methods We searched Pubmed, Cochrane Library, CBM, C.NK1, VIP database in Fobrary, 2011. Randomized controlled trials that met the inclusion criteria wore included and evaluate the quality of them according to the methods of Cochrane systematic review. Meta - analysis was performed by Revman 5. 0. 0. software. Results A total of 13 RCTs involving 1200 patients were included. The result of meta - analysis showed that body temperature after 111 treatment was significant lower with nimesulide than aspirin( MD = 0. 38,95% C7[0. 21 ,0. 55]. P < 0. 000 l) and aminopyrine( MD =0.59,95% C7[0. 19,1. 00], P = 0. 004). As for body temperature after 6 h treatment. significant difference was also found compared to aspirin( MD - 1. 01 , 95% C/[0. 53, 1. 49], P < 0. 000 l) and aminopyrine(MD - 1. 60, 95% Cl[0. 91, 2. 28], P < 0. 000 01 >. Conclusion Current evidence suggests that nimesulide is better than aspirin and aminopyrine in reducing temperature for children with fever. In addition,nimesulide has higher chance in inducing somnolence than aspirin and aminopyrine. More studies are needed to evaluate ADR.关键词
尼美舒利/阿司匹林/复方氨基比林/发热/Meta分析Key words
nimesulide/aspirin/aminopyrine/fever/Meta-analysis分类
医药卫生
