中国组织工程研究与临床康复2011，Vol.15Issue(44)：8341-8343,3.DOI:10.3969/j.issn.1673-8225.2011.44.043
肾移植后他克莫司与五酯胶囊合用致高血钾症1例
Hyperkalemia induced by tacrolimus combined with Wuzhi-capsule following renal transplantation: One case report
陈统清 1林敏娃 1卢结文2
作者信息
- 1. 佛山市第一人民医院肾内科,广东省佛山市 528000
- 2. 佛山市第一人民医院药剂科,广东省佛山市528000
- 折叠
摘要
Abstract
BACKGROUND: Due to the hepatotoxicity induced by immunosuppressant, renal transplantation patients have high incidence ofhepatic dysfunction. When they clinically have hepatic dysfunction, they are in need for hepatic protection treatment. However,the concentration of immunosuppressant must be monitored when hepatinica is added.OBJECTIVE: To explore the effect of the combination of tacrolimus and Wuz/if-capsyle on tacrolimus concentration and bloodbiochemical changes in cases after renal transplantation.METHODS: Retrospective analysis on the tacrolimus concentration, renal function and blood biochemical changes when onecase renal transplantation patient took or stopped taking Wuz/iAcapsule who regarded tacrolimus as the immunosuppressant.The patient performed hemodialysis due to chronic glomemtonephritis and chronic renal insufficiency in June 1998. And receivedrenal transplantation at August 2008. Tacrolimus + mycophenolate * prednisone were adopted after transplantation. Hepaticfunction became abnormal at 4 months after transplantation, and bifendate was added, which was substitute by Wuzhi-capsule atJuly 25. 2010, The medication was stopped on July 29, 2010.RESULTS AND CONCLUSION: If the renal transplantation recipients took tacrolimus their blood tacrolimus concentrationuplifted from 5.3 ng/L to 24.7 ng/L and they were diagnosed with hyperkalemia; if not, their blood tacrolimus concentrationreduced from 24.7 ng/L to 6.1 ng/L and their potassium dropped from 6.4 mmol/L to 4.6 mmol/L. Stable renal transplantationrecipients must have their tacrolimus blood concentration, liver and kidney function, as well as electrolytes monitored after addingWuzhi-capsule; moreover, they should adjust the tacrolimus dosage timely so as to protect renal graft function.关键词
五酯胶囊/肾移植/他克莫司/高钾血症/肾功能分类
医药卫生引用本文复制引用
陈统清,林敏娃,卢结文..肾移植后他克莫司与五酯胶囊合用致高血钾症1例[J].中国组织工程研究与临床康复,2011,15(44):8341-8343,3.
