中国组织工程研究与临床康复2011，Vol.15Issue(44)：8267-8271,5.DOI:10.3969/j.issn.1673-8225.2011.44.025
苦参碱联合环孢素A减轻小鼠急性移植物抗宿主病
Matrine combined with cyclosporin A alleviates acute graft-versus-host-disease after allogeneic bone marrow transplantation in a murine model
张岩 1王旖旎 2冯翠翠 2田莉萍 1李芳 2王昭2
作者信息
- 1. 北京市隆福医院血液科,北京市 100010
- 2. 首都医、科大学附属友谊医院血液科,北京市,100010
- 折叠
摘要
Abstract
BACKGROUND: Malrine can decrease the concentration of interleukin (IL-2) and has been used as a chemotherapy auxiliarymedicine in the clinic.OBJECTIVE: To investigate the effects of matrine and cyclosporin A (CsA) on acute graft-versus-host-disease (aGVHD) afterallogenetic bone marrow transplantation and the possible mechanism of matrine.METHODS: The donors were male C57BL/6 mice, and the recipients were male BABL/C mice. The model of aGVHD in murinewas established by allo-BMT with donor derived T cells. The aGVHD models were randomly divided into seven groups: control,radiation, transplantation, fully quantity CsA. Half quantity CsA, full quantity matrine. Full quantity matrine and half quantity CsA.RESULTS AND CONCLUSIONS: The mouse survival time in the full quantity matrine and half quantity CsA group was longerthan Ihe other groups. Different degrees of pathological changes in aGVHD appeared in each group, and earlier aGVHDoccurrence led to more severe pathological change. At 7 days after transplantation, compared with transplantation group, serumlevel of v -tnterferon was decreased in other groups, but there was no significant difference in IL-4 level between transplantationand other groups. These findings suggest that matrine can prevent letiial aGNHD and prolong mouse survival time afterallogenetic bone marrow transplantation. Matrine exhibits similar effects to CsA, and their combination show better effects thanalone.关键词
苦参碱/环孢素A/异基因骨髓移植/急性移植物抗宿主病/细胞因子分类
临床医学引用本文复制引用
张岩,王旖旎,冯翠翠,田莉萍,李芳,王昭..苦参碱联合环孢素A减轻小鼠急性移植物抗宿主病[J].中国组织工程研究与临床康复,2011,15(44):8267-8271,5.
