重庆医学2011，Vol.40Issue(36)：3689-3690,3693,封3,4.DOI:10.3969/j.issn.1671-8348.2011.36.022
鼻咽癌组织中错配修复基因hMLH1的表达及意义
Expression of mismatch repair gene hMLH1 in tissue of human nasopharyngeal carcinoma and its significance
摘要
Abstract
Objective To explore the expression of mismatch repair gene hMLHl in tissue of human nasopharyngeal carcinoma (NPC) and its relation to clinical pathological features. Methods Two-step immunohistochemistry was employed to detect the expression of hMLHl in 132 tissue samples of NPC and 50 mucosa tissue samples of chronic nasopharyngeal inflammation. Results The positive expression rate of hMLHl in NPC tissue was 55. 30%, which was significantly lower than that(76. 00%) in mucosa tissue of chronic nasopharyngeal inflammation(P<0. 05). The expression of hMLHl in NPC tissue had relationship with T, N staging and clinical staging of NPC as well as the presence of distant metastasis(P<0. 05) , while no relationship with age and gender. Conclusion The expression level of hMLHl decreases in NPC tissue and hMLHl may serve as one of biological markers to predict the prognosis of NPC.关键词
鼻咽肿瘤/免疫组织化学/人类mut1同源物1基因Key words
nasopharyngeal neoplasms/immunohistochemistry/human mutl homolog 1引用本文复制引用
谭晓虹,刘志辉,岑洪,李刚,劳永聪..鼻咽癌组织中错配修复基因hMLH1的表达及意义[J].重庆医学,2011,40(36):3689-3690,3693,封3,4.基金项目
广西壮族自治区卫生厅广西医疗卫生重点科研课题资助项目(200967). （200967）
